pH-dependent ileocolonic drug delivery, part II: preclinical evaluation of novel drugs and novel excipients.
作者： Annemarie Broesder , Anne-Marijke M.A.C. Kosta , Herman J. Woerdenbag , Duong N. Nguyen , Henderik W. Frijlink
DOI: 10.1016/J.DRUDIS.2020.06.012
关键词:
摘要: Novel drugs and novel excipients in pH-dependent ileocolonic drug delivery systems have to be tested animals. Which animal species are suitable what vivo methods used verify delivery?
sci-hub.st 参考文章(162)
P Boulos, D Anthony, V Sams, F Savage, The characterization of a rabbit model of inflammatory bowel disease. International Journal of Experimental Pathology. ,vol. 76, pp. 215- 224 ,(1995)
Takashi Sugimura, Experimental tumors in digestive organs Gastroenterologia Japonica. ,vol. 11, pp. 265- 266 ,(1976) , 10.1007/BF02777712
Parviz Mojaverian, Keith Chan, Anil Desai, Vivian John, Gastrointestinal transit of a solid indigestible capsule as measured by radiotelemetry and dual gamma scintigraphy Pharmaceutical Research. ,vol. 6, pp. 719- 724 ,(1989) , 10.1023/A:1015998708560
Klaus Ewe, Inflammation does not decrease intraluminal pH in chronic inflammatory bowel disease. Digestive Diseases and Sciences. ,vol. 44, pp. 1434- 1439 ,(1999) , 10.1023/A:1026664105112
J.E. Kellow, T.J. Borody, S.F. Phillips, A.C. Haddad, M.L. Brown, Sulfapyridine appearance in plasma after salicylazosulfapyridine Gastroenterology. ,vol. 91, pp. 396- 400 ,(1986) , 10.1016/0016-5085(86)90574-3
David M. Grayzel, Edgar G. Miller, The pH of the Contents of the Gastrointestinal Tract in Dogs, in relation to Diet and Rickets. Journal of Biological Chemistry. ,vol. 76, pp. 423- 436 ,(1928) , 10.1016/S0021-9258(18)84086-8
Parviz Mojaverian, Peter H. Vlasses, Paul E. Kellner, Mario L. Rocci, Jr., Effects of Gender, Posture, and Age on Gastric Residence Time of an Indigestible Solid: Pharmaceutical Considerations Pharmaceutical Research. ,vol. 5, pp. 639- 644 ,(1988) , 10.1023/A:1015922903843
Jan Fallingborg, Poul Pedersen, Bent A. Jacobsen, Small Intestinal Transit Time and Intraluminal pH in Ileocecal Resected Patients with Crohn's Disease Digestive Diseases and Sciences. ,vol. 43, pp. 702- 705 ,(1998) , 10.1023/A:1018893409596
Rabin Bs, Animal model: immunologic model of inflammatory bowel disease. American Journal of Pathology. ,vol. 99, pp. 253- 256 ,(1980)
Darryl N. Biery, Jerry M. Owens, Radiographic Interpretation for the Small Animal Clinician ,(1982)