Effect of rectal infusion of short chain fatty acids in human subjects.

摘要: Solutions containing 90 mmol sodium acetate plus 30 propionate (90 mM; isotonic), 180 60 (180 hypertonic) or an equivalent volume of isotonic saline were given over a 30-min period in random order by rectal infusion to six healthy subjects. Peripheral venous blood samples obtained at intervals the next 2 h. After mM infusion, serum response reached peak min and had fallen baseline 120 min. The incremental area under curve after was twice that mM. Propionate undetectable any time. Blood glucose fell all infusions, but there no significant difference between saline- short chain fatty acid (SCFA)-containing infusions. SCFA effect on insulin c-peptide concentrations. However, compared with control, solution resulted fall free-fatty acids (FFA) rise total cholesterol triglyceride, change beta-hydroxybutyrate levels. data provide strong evidence colonic are absorbed metabolized human subject. FFA suggests have carbohydrate metabolism. In addition, indirect for utilization lipid synthesis.