Association Between Prenatal Exposure to Bacterial Infection and Risk of Schizophrenia

摘要: Recent research suggests that prenatal exposure to nonviral infection may be associated with increased risk of schizophrenia, and we hypothesized an association between maternal bacterial during pregnancy elevated offspring schizophrenia. Data on infections from the Copenhagen Perinatal Cohort were linked Danish National Psychiatric Register. Offspring cases narrowly defined schizophrenia (International Classification Diseases, Eighth Revision [ICD-8]) more broadly (ICD-8 ICD-10) identified before ages 32–34 45–47 years, respectively. The effect was adjusted for analgesics parental social status. In a set 7941 individuals, 85 (1.1%) ICD-8 by age years 153 (1.9%) years. First-trimester conferred (odds ratio 2.53; 95% confidence interval [CI] 1.07–5.96) also 2.14; CI 1.06–4.31). Secondtrimester significantly but only in unadjusted analyses. These findings suggest relationship this somewhat stronger earlier onset. Post hoc analyses showed upper respiratory tract gonococcal disease. An might mediated through transplacental passage maternally produced cytokines response infections.