The applications of buckminsterfullerene C60 and derivatives in orthopaedic research
作者： Qihai Liu , Quanjun Cui , Xudong Joshua Li , Li Jin
DOI: 10.3109/03008207.2013.877894
关键词:
摘要: AbstractBuckminsterfullerene C60 and derivatives have been extensively explored in biomedical research due to their unique structure unparalleled physicochemical properties. is characterized as a “free radical sponge” with an anti-oxidant efficacy several hundred-fold higher than conventional anti-oxidants. Also, the core has strong electron-attracting ability numerous functional compounds widely different properties can be added this fullerene cage. This review focused on applications of orthopaedic research, such treatment cartilage degeneration, bone destruction, intervertebral disc degeneration (IVDD), vertebral marrow disorder, radiculopathy, etc., well toxicity vitro vivo. We suggest that derivatives, especially cores coupled groups presenting new biological pharmacological activities, are advantageous will promising clinical performance for ...
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