Effects of Depsidones from Hypogymnia physodes on HeLa Cell Viability and Growth
作者： Najdanović J , Vasiljević P , Smelcerović A , Najman S , Jovanović O
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摘要: The anti-proliferative activitiy of Hypo gymnia physodes methanol extracts (ME) and its main constituents, physodalic acid (P1), physodic (P2), 3-hydroxy (P3), was tested on human cancer HeLa cell lines. Three lichen depsidones, P1, P2 P3, were isolated from H. ME using column chromatography their structures determined by UV, ESI TOF MS, 1 H 13 C NMR. content P3 in reversed-phase high- performance liquid with photodi- ode array detection. P1-3 represented even 70 % the studied extract. cells incubated during 24 72 h presence depsi- dones at concentrations 10-1000 μg/ml. Compounds showed higher activity than compound P1. Half maximal inhibitory concen- trations (IC 50 , μg/ml) P2, for 24-h incubation 964, 171, 97 254 μg/ml, respec- tively, while 72-h they 283, 66, 63 68 As far as we know, this is first re- port effect cells.
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