High-dose-rate versus low-dose-rate intracavitary therapy for carcinoma of the uterine cervix: a randomized trial.

摘要: BACKGROUND This was a prospective randomized clinical trial undertaken at our institution to compare low-dose-rate (LDR) intracavitary radiation therapy versus high-dose-rate (HDR) for the treatment of cervical carcinoma. METHODS From January 1984 December 1997, total 132 patients with Stage II or IIIB invasive carcinoma uterine cervix were entered into this study. Treatment arm by HDR LDR allocated according month each patient's birth. External irradiation consisted whole pelvis and pelvic irradiation. Doses external both groups identical. The authors used 0.588 as conversion factor dose from HDR. RESULTS The 5-year disease specific survival rates III treated 69% 51% whereas those 87% 60%, respectively. recurrence free 89% 73% 100% 70%, There no significant difference in between LDR. actuarial complication rate (Radiation Therapy Oncology Group Grade 3, 4, 5) 5 years 10% group 13% group, not statistically significant. CONCLUSIONS The control comparable treatment. III, although II, appeared have better than HDR. Cancer 2002;94:117–24. © 2002 American Society.