Integrated Approaches to Blood–Brain Barrier
作者： Haojing Rong , Bo Feng , Li Di
DOI: 10.1002/9780470921920.EDM067
关键词:
摘要: In vivo, in vitro and silico methodologies are discussed to address the challenges of CNS drug discovery development. The most important parameter that governs vivo pharmacology is free concentration at site action brain. Four different approaches can be used estimate human Lessons learned on prediction successes highlighted using thirty-two Pfizer clinical candidates with CSF and/or receptor occupancy data. Keywords: blood brain barrier; brain penetration prediction; CSF; BCSF; P-gp
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