Impaired Maternal Behavior in Usp46 Mutant Mice: A Model for Trans-Generational Transmission of Maternal Care

摘要: Usp46 mutant mice (congenic strain on a B6 genetic background; MT mice) have low weaning rate and display poor maternal behavior compared to C57BL/6J (B6 mice). Based these observations, we examined how is shaped by cross-fostering in-fostering mice. The experiments consisted of six groups: fostered their biological mother (B6-CO); (MT-CO); different (B6-IF); (MT-IF); an (B6-CF); (MT-CF). Maternal was assessed using the pup-retrieval test in adult female offspring, four parameters, time nursing pups nest, sniffing or licking pups, rearing behavior, latency retrieve were measured. Cross-fostering significantly reduced spent sniffing/licking pup, increased number instances B6-CF group, improved three parameters behaviors (nursing, latency) MT-CF group. These results indicate that level care transmitted proper can be if adequate postpartum given, even genetically vulnerable However, offspring’s genotype may also influence development adulthood. Thus, prove useful as model for trans-generational transmission care, findings provide insight into mechanisms maltreating human child abuse.