Post-thymic T cell lymphomas frequently overexpress p53 protein but infrequently exhibit p53 gene mutations

摘要: We recently demonstrated that only one of 36 T-cell neoplasms contained p53 gene mutations. Although mutations are known to result in overexpression the product, we also discovered protein does not correlate with mutations, but proliferation (r = 0.92), anaplastic large cell lymphoma. In view these findings, investigated 34 non-human lymphotropic virus type I (HTLV-I) related postthymic lymphomas immunohistochemically for protein, using monoclonal antibody 1801, and proliferation, Ki-67, quantitated results CAS-200 computerized image analysis system. evaluated presence conserved exons 5 9 single-strand conformation polymorphism DNA sequencing. were detected three cases, including two deletions. was 17 mutated reactivities ranging from 10% 48%. However, many cases which a structural alteration could be levels expression comparable those mutated. Correlation as assessed by Ki-67 expression, this group poor 0.34). Whether alternative mechanisms inactivation causing phenotypic malignant is unknown, although preliminary studies do support major role such mechanisms. Therefore, etiology significance lack demonstrable mutation unclear. Nevertheless, lymphoma, product reliable predictor portions non-HTLV-I associated post-thymic