Highly stereoselective titanium-mediated aldol reactions from chiral α-silyloxy ketones. A reliable tool for the synthesis of natural products
作者： Judit Esteve , Carme Jiménez , Joaquim Nebot , Javier Velasco , Pedro Romea
DOI: 10.1016/J.TET.2011.06.019
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摘要: Abstract Chiral α-silyloxy ketones participate in highly stereoselective TiCl4-mediated aldol reactions that afford diastereomerically pure syn–syn adducts high yield irrespective of the R1 and R2 substituents flanking carbonyl or silicon protecting group. Further manipulation resulting provide a straightforward manner functionalized fragments facilitate synthesis natural products.
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