Synthesis and dopaminergic binding of 2-aryldopamine analogues: phenethylamines, 3-benzazepines, and 9-(aminomethyl)fluorenes.

摘要: A series of 2-aryldopamine analogues were synthesized and evaluated for their effects on D1 D2 dopamine receptors. The 2-phenyldopamine 6-phenylbenzazepine exhibited weak binding to both 9-(aminomethyl)fluorenes also binding; however, 2,5,6-trihydroxy-9H-fluorene-9-methanamine (4b) comparable apomorphine. activity has been correlated with the calculated torsion angle biphenyl portion these molecules. Good occurs when aromatic rings approach coplanarity; poor are orthogonal.