Modified Microcapsules of Calcium Alginate for Controlled Release of Antitumor Drug Cyclophosphamide

摘要: The aim of this paper is the development controlled delivery system immobilized by antitumor drug cyclophosphamide on basis microparticles calcium alginate gel, modified natural polymer chitosan. Modified were obtained syringed dropwise cyclophosphamide-containing solution sodium into a chitosan in chloride. consisting covered surface layer Formation polyelectrolyte complex between polycation and polyanion stabilized ionic bonds was observed. release from gel particles physiological with different thickness coating studied. It shown that characteristic maximum curve observe after 10, 30, 90 120 mm for samples without 55, 100 150 μm, respectively. data possibility regulation rate through coating.