Effect of energy depletion on the glycosylation of a viral glycoprotein.
作者： R. Datema , R.T. Schwarz
DOI: 10.1016/S0021-9258(19)68576-5
关键词:
摘要: In energy-depleted cells the formation of mannosylphosphoryldolichol is inhibited. Glucosyl-phosphoryldolichol, di-N-acetylchitobiosyl-pyrophosphoryl-dolichol and also GDP-mannose are still present, indicating that mannosyl-phosphoryl-dolichol hence glycosylation proteins via lipid-linked oligosaccharide (Glc)3(Man)9(GlcNAc)2-pyrophosphoryl-dolichol, under metabolic control. endo-beta-N-acetylglucosaminidase H-resistant, oligosaccharides (Man)x(GlcNAc)2-pyrophosphoryl-dolichol (X = 1 to 5) formed. Despite absence protein not blocked. The influenza virus hemagglutinin glycosylated with but complex, oligosaccharides. These can be processed protein-linked (Man)5(GlcNAc)2 (Man)4(GlcNAc)2, may represent glucosylated species. However, rate at which leaves rough endoplasmic reticulum and, probably therefore, oligosaccharide-processing decreased in cells. Both inhibition intracellular migration reserved when energy status brought back normal levels.
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