Rebamipide induces the gastric mucosal protective factor, cyclooxygenase-2, via activation of 5′-AMP-activated protein kinase

摘要: Rebamipide, an amino acid derivative of 2(1H)-quinolinone, has been used for mucosal protection, healing gastroduodenal ulcers, and treatment gastritis. Induction cyclooxygenase (COX)-2, a gastric protective factor, by rebamipide suggested as the major mechanism drug action. However, how induces COX-2 at molecular level needs further investigation. In this study, underlying induction was investigated. carcinoma cells macrophage cells, induced phosphorylation AMP-activated protein kinase (AMPK), leading to acetyl-CoA carboxylase (ACC), substrate AMPK. The dependent on AMPK activation because compound C, inhibitor, abolished rebamipide. mouse ulcer model, protected against hydrochloric acid/ethanol-induced ulcer, these effects were deterred co-administration C. parallel, in tissues, increased AMPK, whereas C reduced levels phosphorylated ACC, which Taken together, may be that contributes COX-2, probably resulting protection ulcers.