Protein Phosphatase 1 as a Potential Mediator of Aluminum Neurotoxicity

摘要: It has been well established that exposure to metals leads learning and memory deficits as the onset of anomalies associated with a wide range neuropathological disorders. Simultaneously serine/threonine protein phosphatases, in particular phosphatase 1 (PP1), are pivotal regulatory proteins, key modulating signaling cascades neuronal responses. Among these Glutamatergic, GABAergic, Serotonergic Dopaminergic systems, all which can be negatively affected by metal exposure. In fact some metals, like aluminum, arsenic lead directly affect PP1. Another characteristic neuropathologies is aggregation. Some proteins aggregate their hyperphosphorylated form decreased activities have reported. Furthermore, deposition often aggregates. Whether PP1 link between above-mentioned neurotoxic effects remains an intensive area research, but existing data places it very strong candidate. Thus most relevant putative associations PP1, neurotoxicity manner, here discussed.