摘要: Epithelial to mesenchymal transition (EMT) is a critical event in embryogenesis and plays fundamental role cancer progression metastasis. Numb has been shown play an important the proper functions of Par protein complex cell-cell junctions, both which are associated with EMT. However, EMT not fully elucidated. Recently, we showed that capable binding Par3 E-cadherin. Intriguingly, interaction E-cadherin or dynamically regulated by tyrosine phosphorylation induced HGF Src. Knockdown shRNA MDCK cells led lateral apical translocation beta-catenin, active F-actin polymerization, mis-localization aPKC, decrease adhesion increase cell migration proliferation. These data suggest diverse for regulating adhesion, polarity during
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