Rubella virus-specific humoral immune responses and their interrelationships before and after a third dose of measles-mumps-rubella vaccine in women of childbearing age
作者： Iana H. Haralambieva , Inna G. Ovsyannikova , Richard B. Kennedy , Krista M. Goergen , Diane E. Grill
DOI: 10.1016/J.VACCINE.2019.11.004
关键词:
摘要: Abstract In the U.S., measles, mumps, and rubella vaccination is recommended as two vaccine doses. A third dose of measles-mumps-rubella (MMR) being administered in certain situations (e.g., identified seronegativity during outbreaks). We studied rubella-specific humoral immunity (neutralizing antibody, enzyme-linked immunosorbent assay/ELISA IgG titer antibody avidity) frequencies antigen-specific memory B cells before after a MMR-II 109 female participants childbearing age (median age, 34.5 years old) from Olmsted County, MN, with documented prior MMR The were selected cohort 1117 individuals if they represented high low ends response spectrum. Of participants, we four (3.67% all study participants; 7.14% low-responder group) that seronegative at Baseline (rubella-specific ELISA titers
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