Flushing Out Carcinoid Syndrome: Beneficial Effect of the Anticancer Epigenetic Agent RRx-001 in a Patient with a Treatment-Refractory Neuroendocrine Tumor.
作者： Corey A. Carter , Aiste Degesys , Bryan Oronsky , Jan Scicinski , Scott Z. Caroen
DOI: 10.1159/000441775
关键词:
摘要: Neuroendocrine tumors (NET) are a heterogeneous group of neoplasms defined by the presence cells with secretory granules and potential to produce release high levels vasoactive peptides into circulation, leading severe flushing diarrhea, which may adversely affect quality life. This report presents case 64-year-old man chronic refractory diarrhea due pulmonary NET treated experimental anticancer agent RRx-001 in phase II trial called TRIPLE THREAT subsequent resolution his diarrhea.
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sci-hub.se 参考文章(10)
Bryan T. Oronsky, Arnold L. Oronsky, Michelle Lybeck, Neil C. Oronsky, Jan J. Scicinski, Corey Carter, Regina M. Day, Jose F. Rodriguez Orengo, Maribel Rodriguez-Torres, Gary F. Fanger, Tony R. Reid, Episensitization: Defying Time’s Arrow Frontiers in Oncology. ,vol. 5, pp. 134- 134 ,(2015) , 10.3389/FONC.2015.00134
Bryan T. Oronsky, Jan J. Scicinski, Tony Reid, Susan Knox, Beyond Antiangiogenesis: Vascular Modulation as an Anticancer Therapy—A Review Translational Oncology. ,vol. 5, pp. 133- 140 ,(2012) , 10.1593/TLO.12118
Garth Bissette, Paul Manberg, Charles B. Nemeroff, Arthur J. Prange, Neurotensin, a biologically active peptide. Life Sciences. ,vol. 23, pp. 2173- 2182 ,(1978) , 10.1016/0024-3205(78)90201-1
Jan Scicinski, Bryan Oronsky, Shoucheng Ning, Andrew Minchinton, Susan Knox, Abstract 4371: RRx-001 modulates intratumor blood flow in SCCVII and U87 tumors Cancer Research. ,vol. 72, pp. 4371- 4371 ,(2012) , 10.1158/1538-7445.AM2012-4371
Bryan Oronsky, Corey A. Carter, Vernon Mackie, Jan Scicinski, Arnold Oronsky, Neil Oronsky, Scott Caroen, Christopher Parker, Michelle Lybeck, Tony Reid, The war on cancer: a military perspective Frontiers in Oncology. ,vol. 4, pp. 387- 387 ,(2015) , 10.3389/FONC.2014.00387
Dean D. Metcalfe, Differential diagnosis of the patient with unexplained flushing/anaphylaxis. Allergy and Asthma Proceedings. ,vol. 21, pp. 21- 24 ,(2000) , 10.2500/108854100778249006
Jennifer R. Eads, Neal J. Meropol, A New Era for the Systemic Therapy of Neuroendocrine Tumors Oncologist. ,vol. 17, pp. 326- 338 ,(2012) , 10.1634/THEONCOLOGIST.2011-0356
Tony Reid, Bryan Oronsky, Jan Scicinski, Curt L Scribner, Susan J Knox, Shoucheng Ning, Donna M Peehl, Ron Korn, Meaghan Stirn, Corey A Carter, Arnold Oronsky, Michael J Taylor, William L Fitch, Pedro Cabrales, Michelle M Kim, Howard A Burris, Christopher D Lao, Nacer E D Abrouk, Gary R Fanger, Jeffrey R Infante, Safety and activity of RRx-001 in patients with advanced cancer: a first-in-human, open-label, dose-escalation phase 1 study The Lancet Oncology. ,vol. 16, pp. 1133- 1142 ,(2015) , 10.1016/S1470-2045(15)00089-3
W.D. Travis, Advances in neuroendocrine lung tumors Annals of Oncology. ,vol. 21, ,(2010) , 10.1093/ANNONC/MDQ380
A.-J. Van Der Lely, S. W. J. Lamberts, W. W. De Herder, A. J. J. Wood, Ll. J. Hofland, Drug therapy : octreotide The New England Journal of Medicine. ,vol. 334, pp. 246- 254 ,(1996)