Glycyrrhizic acid inhibits apoptosis and fibrosis in carbon-tetrachloride-induced rat liver injury
作者： Bo Liang
关键词:
摘要: AIM: To investigate anti-apoptotic effects of glycyrrhizic acid (GA) against fibrosis in carbon tetrachloride (CCl4)-induced liver injury and its contributing factors. METHODS: Liver was induced by administration CCl4 for 8 wk. Pathological changes the rats were examined hematoxylin-eosin staining. Collagen fibers detected Sirius red Hepatocyte apoptosis determined TUNEL assay expression levels cleaved caspase-3, Bax, α-SMA, connective tissue growth factor (CTGF), matrix metalloproteinase (MMP) 2 MMP9 proteins evaluated western blot analysis, α-SMA mRNA, collagen type I and III mRNA estimated real-time PCR. RESULTS: Treatment with GA significantly improved pathological markedly decreased positive area compared CCl4-treated group. showed that reduced number TUNEL-positive cells The CTGF, MMP2 proteins, also group (P < 0.05). CONCLUSION: treatment can ameliorate CCl4-induced inhibiting hepatocyte hepatic stellate cell activation.
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