Developing an agenda for translational studies of resilience and vulnerability following trauma exposure.

摘要: Here we outline a translational research agenda for studies of resilience, defined as the process adapting well in face adversity or trauma. We argue that an individual differences approach to study which full range behavioral and biological responses stress exposure is examined can be applied across human samples (e.g., people who have developed psychopathology versus those not; been exposed trauma not) even, some cases, species. delineate important psychological resilience-related factors including positive affectivity optimism, cognitive flexibility, coping, social support, emotion regulation, mastery. Key brain regions associated with stress-related identified animal models fear extinction conditioning; memory reconsolidation) describe how these studied humans using neuroimaging technology. Finally, cite recent identifying neuroendocrine markers resilience recovery neuropeptide Y [NPY], dehydroepiandrosterone [DHEA]) also measured, other That does not necessarily lead impairment development all observation. Understanding why this so will provide clues therapeutic interventions do develop psychopathology, even prevention adverse outcomes.