Desmopressin in treatment of haematological disorders and in prevention of surgical bleeding.
作者： Peter J. Svensson , Peter B.F. Bergqvist , Kristian Vinter Juul , Erik Berntorp
DOI: 10.1016/J.BLRE.2014.03.001
关键词:
摘要: Stimulation with the vasopressin analogue desmopressin (DDAVP) of extrarenal arginine (AVP) V2-receptors in endothelial cells and possible platelets increases circulating levels coagulation factor VIII (FVIII), von Willebrand (VWF) tissue plasminogen activator (t-PA). The purpose this paper is to provide an updated review current information on efficacy safety DDAVP treatment haemophilia, disease (VWD), uremia, liver cirrhosis, congenital or drug-induced platelet dysfunction--under surgical non-surgical conditions. In summary, effective haemostatic drug that when administered i.v., s.c. intranasally plasma FVIII VWF 2-6 times improves function. It has a proven mild haemophilia A VWD as well cirrhosis acquired, induced dysfunction. Desmopressin few side effects but observation advised small children elderly.
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