Hyperthermia induced HIF-1a expression of lung cancer through AKT and ERK signaling pathways

作者: Jun Wan , Wei Wu

DOI: 10.1186/S13046-016-0399-7

关键词:

摘要: Background Hyperthermia is a promising treatment for human lung cancer, but recurrence of the primary lesion common, as residual tumor becomes adapted to heat and growth induced by hypoxia-triggered HIF-1a expression. Here, we explored effects hyperthermia on expression, proliferation, cancer angiogenesis.

参考文章(35)
Jun Wan, Wei Wu, Yun Che, Ningning Kang, RenQuan Zhang, Low dose photodynamic-therapy induce immune escape of tumor cells in a HIF-1α dependent manner through PI3K/Akt pathway. International Immunopharmacology. ,vol. 28, pp. 44- 51 ,(2015) , 10.1016/J.INTIMP.2015.05.025
Jun Wan, Jinben Ma, Ju Mei, Genfa Shan, The effects of HIF-1alpha on gene expression profiles of NCI-H446 human small cell lung cancer cells. Journal of Experimental & Clinical Cancer Research. ,vol. 28, pp. 150- 150 ,(2009) , 10.1186/1756-9966-28-150
Rachida S. BelAiba, Steve Bonello, Christian Zähringer, Stefanie Schmidt, John Hess, Thomas Kietzmann, Agnes Görlach, Hypoxia Up-Regulates Hypoxia-Inducible Factor-1α Transcription by Involving Phosphatidylinositol 3-Kinase and Nuclear Factor κB in Pulmonary Artery Smooth Muscle Cells Molecular Biology of the Cell. ,vol. 18, pp. 4691- 4697 ,(2007) , 10.1091/MBC.E07-04-0391
Hideo Gobara, Hiroyasu Fujiwara, Hiroaki Ishii, Koji Tomita, Mayu Uka, Satoko Makimoto, Susumu Kanazawa, Takao Hiraki, Lung cancer ablation: complications. Seminars in Interventional Radiology. ,vol. 30, pp. 169- 175 ,(2013) , 10.1055/S-0033-1342958
Qiu-li Zhang, Bai-ri Cui, Hai-yan Li, Ping Li, Lan Hong, Li-ping Liu, Da-zhi Ding, Xun Cui, MAPK and PI3K pathways regulate hypoxia-induced atrial natriuretic peptide secretion by controlling HIF-1 alpha expression in beating rabbit atria Biochemical and Biophysical Research Communications. ,vol. 438, pp. 507- 512 ,(2013) , 10.1016/J.BBRC.2013.07.106
Masato Inazu, Tomoko Yamada, Nobuo Kubota, Tsuyoshi Yamanaka, Functional expression of choline transporter-like protein 1 (CTL1) in small cell lung carcinoma cells: A target molecule for lung cancer therapy Pharmacological Research. ,vol. 76, pp. 119- 131 ,(2013) , 10.1016/J.PHRS.2013.07.011
Nobuyuki Matsumoto, Koichi Obara, Norie Yamada, Masaru Okamoto, Minoru Kobayashi, Hideaki Takahashi, Yoshiki Katakura, Kotaro Matsunago, Toshiya Ishii, Chiaki Okuse, Michihiro Suzuki, Fumio Itoh, None, Insufficient radiofrequency ablation therapy may induce further malignant transformation of hepatocellular carcinoma Hepatology International. ,vol. 2, pp. 116- 123 ,(2008) , 10.1007/S12072-007-9040-3
Hua Yao, Huiming Wang, Zhuo Zhang, Bing‐Hua Jiang, Jia Luo, Xianglin Shi, Sulforaphane inhibited expression of hypoxia‐inducible factor‐1α in human tongue squamous cancer cells and prostate cancer cells International Journal of Cancer. ,vol. 123, pp. 1255- 1261 ,(2008) , 10.1002/IJC.23647
Daniel Edmund Bryan Swinson, Kenneth John O'Byrne, Interactions between hypoxia and epidermal growth factor receptor in non-small-cell lung cancer. Clinical Lung Cancer. ,vol. 7, pp. 250- 256 ,(2006) , 10.3816/CLC.2006.N.002