Biological role of the CCAAT/enhancer-binding protein family of transcription factors
作者： Julie Lekstrom-Himes , Kleanthis G. Xanthopoulos
关键词:
摘要: CCAAT/enhancer-binding proteins (C/EBPs) comprise a family of transcription factors that are critical for normal cellular differentiation and function in variety tissues. The prototypic C/EBP is modular protein, consisting an activation domain, dimerization bZIP region, DNA-binding domain. All members share the highly conserved required DNA binding, by which they form homo- heterodimers with other members. C/EBPs least their domains vary from strong activators to dominant negative repressors. pleiotropic effects part because tissue- stage-specific expression. Dimerization different precisely modulates transcriptional activity target genes. Recent work mice deficient specific underscores these tissue development, function, response injury.
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