Tbx15 Defines a Glycolytic Subpopulation and White Adipocyte Heterogeneity.
作者： Kevin Y. Lee , Rita Sharma , Grant Gase , Siegfried Ussar , Yichao Li
DOI: 10.2337/DB17-0218
关键词:
摘要: Tbx15 is a member of the T-box gene family mesodermal developmental genes. We have recently shown that plays critical role in formation and metabolic programming glycolytic myofibers skeletal muscle. also differentially expressed among white adipose tissue (WAT) different body depots. In current study, using three independent methods, we show even within single WAT depot, high expression restricted to subset preadipocytes mature adipocytes. Gene profiling demonstrate Tbx15Hi preadipocyte adipocyte subpopulations cells are highly glycolytic, whereas Tbx15Low adipocytes same depot more oxidative less glycolytic. Likewise, humans, TBX15 subcutaneous visceral positively correlated with markers metabolism inversely obesity. Furthermore, overexpression sufficient reduce increase cultured Thus, regulates preadipocytes. This leads functional heterogeneity cellular has potential impact understanding human diseases.
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