Synergy between baicalein and penicillins against penicillinase-producing Staphylococcus aureus
作者： Minyi Qian , Shusheng Tang , Congming Wu , Yang Wang , Tao He
DOI: 10.1016/J.IJMM.2015.05.001
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摘要: Abstract The combination of baicalein (the active constituent Scutellaria baicalensis ) with penicillin G/amoxicillin showed potent synergy against 20 clinical penicillinase-producing Staphylococcus aureus strains including 10 isolates that were additionally methicillin-resistant (MRSA). fractional inhibitory concentration (FIC) indices penicillins + baiclein ranged from 0.14 to 0.38. Baicalein protected penicillins (penicillin G and amoxicillin) penicillinase increased the susceptibility penicillinase-supplemented S. ATCC 29213 in a dose-dependent manner. inhibition activity by should be responsible for synergism protective effect. These findings offer us good evidence combined synergistic MRSA vitro might provide promising implications treatment these bacterial infections.
sci-hub.se 参考文章(34)
S. Coulton, I. François, 6 β-Lactamases: Targets for Drug Design Progress in Medicinal Chemistry. ,vol. 31, pp. 297- 349 ,(1994) , 10.1016/S0079-6468(08)70023-7
Michael S. Maddux, Effects of ß-Lactamase-Mediated Antimicrobial Resistance: The Role of ß-Lactamase Inhibitors Pharmacotherapy. ,vol. 11, ,(1991) , 10.1002/J.1875-9114.1991.TB02618.X
K Okita, Q Li, T Murakamio, M Takahashi, Anti-growth effects with components of Sho-saiko-to (TJ-9) on cultured human hepatoma cells European Journal of Cancer Prevention. ,vol. 2, pp. 169- 176 ,(1993) , 10.1097/00008469-199303000-00010
Dengfeng Wang, Zhicai Wang, Zuoting Yan, Jianyong Wu, Tariq Ali, Jianjun Li, Yanli Lv, Bo Han, None, Bovine mastitis Staphylococcus aureus: antibiotic susceptibility profile, resistance genes and molecular typing of methicillin-resistant and methicillin-sensitive strains in China. Infection, Genetics and Evolution. ,vol. 31, pp. 9- 16 ,(2015) , 10.1016/J.MEEGID.2014.12.039
Henry Chambers, The changing epidemiology of Staphylococcus aureus Emerging Infectious Diseases. ,vol. 7, pp. 178- 182 ,(2001) , 10.3201/EID0702.010204
Min Li, Aixin Shi, Hongxian Pang, Wei Xue, Yang Li, Guoying Cao, Bei Yan, Fan Dong, Kexin Li, Wei Xiao, Guorong He, Guanhua Du, Xin Hu, Safety, tolerability, and pharmacokinetics of a single ascending dose of baicalein chewable tablets in healthy subjects. Journal of Ethnopharmacology. ,vol. 156, pp. 210- 215 ,(2014) , 10.1016/J.JEP.2014.08.031
Jianchu Chen, Zhaoliang Li, Allen Chen, Xingqian Ye, Haitao Luo, Gary Rankin, Yi Chen, Inhibitory effect of baicalin and baicalein on ovarian cancer cells. International Journal of Molecular Sciences. ,vol. 14, pp. 6012- 6025 ,(2013) , 10.3390/IJMS14036012
Vincent Peton, Yves Le Loir, Staphylococcus aureus in veterinary medicine Infection, Genetics and Evolution. ,vol. 21, pp. 602- 615 ,(2014) , 10.1016/J.MEEGID.2013.08.011
H. Wagner, G. Ulrich-Merzenich, Synergy research: Approaching a new generation of phytopharmaceuticals Phytomedicine. ,vol. 16, pp. 97- 110 ,(2009) , 10.1016/J.PHYMED.2008.12.018
E. Keleti, C. W. Norden, H. Wentzel, Comparison of Techniques for Measurement of in Vitro Antibiotic Synergism The Journal of Infectious Diseases. ,vol. 140, pp. 629- 633 ,(1979) , 10.1093/INFDIS/140.4.629