2 DNA damage in folate deficiency
作者： Benjamin C. Blount , Bruce N. Ames
DOI: 10.1016/S0950-3536(05)80216-1
关键词:
摘要: Summary Folate deficiency significantly increases uracil content and chromosome breaks (as measured by micronucleated cells) in human leukocyte DNA. supplementation reduces both the of DNA frequency cells, indicating that misincorporation may play a causative role folate deficiency-induced breaks. A calculation is presented to explain how levels found could cause Based on this calculation, repair events might result double-strand 1752-fold. These results are consistent with clinical epidemiological evidence linking damage cancer.
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