The effects of vitamin D supplementation on hepatic dysfunction, vitamin D status, and glycemic control in children and adolescents with vitamin D deficiency and either type 1 or type 2 diabetes mellitus.

摘要: Background The effects of vitamin D supplementation on mild hepatic dysfunction and glycemic control are unclear in children adolescents with either type 1 (T1D) or 2 diabetes (T2D). Hypothesis Vitamin will improve control. Aim To determine the effect alanine transaminase (ALT), hemoglobin A1c (HbA1c), serum 25-hydroxyvitamin [25(OH)D] concentration. Subjects Methods A retrospective study 131 subjects T1D (n = 88∶46 females, 42 males), T2D 43∶26 17 males) ages 3–18 years between 2007–2013. All had (1) a diagnosis for >12 mo, (2) received management deficiency (3) baseline subsequent simultaneous measurements HbA1c, ALT, 25(OH)D. Vitamin was defined as 25(OH)D concentration <50 nmol/L (20 ng/mL). Results At baseline, occurred 72.1% patients 37.5% (p<0.001). Patients significantly higher values BMI SDS (p<0.001), (ALT) (p 0.001), but lower no difference HbA1c 0.94), total daily dose (TDD) insulin per kg body weight 0.48) compared to patients. After 3 months supplementation, there significant increase both 0.015), (p<0.001); reduction 0.015) ALT 0.012) T2D, not T1D. There clinically-significant decrease from 8.5±2.9% at 7.7±2.5 T1D, 8.5±1.2 8.53±1.1%. Conclusions associated statistically decreases SDS, HbA1c.