Pharmacokinetics of Josamycin in patients with liver cirrhosis and Gilbert's syndrome after repeated doses.

摘要: The pharmacokinetics of Josamycin was studied in 31 subjects (10 normals, 9 Gilbert's syndrome and 12 compensated liver cirrhosis) after the administration (1 g orally) 13 (4 4 5 3-day treatment orally every hours). impaired cirrhosis and, to a lesser extent, syndrome. Moreover, three groups individuals drug accumulated multiple dosing. These results suggest that dosage adjustment is recommended when dealing with these patients.