Impact of Natural Selection Due to Malarial Disease on Human Genetic Variation
作者： Felicia Gomez , Wen-Ya Ko , Avery Davis , Sarah A. Tishkoff
DOI: 10.1007/978-1-4614-7181-3_5
关键词:
摘要: Malaria is an important selective pressure in modern human evolution. The dynamic relationship between hosts and Plasmodium parasites has left numerous “footprints” of natural selection within the genomes both host parasite. In this chapter we describe evolutionary impact malaria, caused by infection, on genetic diversity. Specifically, focus patterns variation that alter hemoglobin structure red blood cell function. We also discuss nucleotide at loci involved malaria pathogenesis immune defense. different types could underlie observed diversity each locus. Finally, discusses future directions for study host/pathogen coevolution. These include departure from single-gene studies growing application genomic methodologies identification novel functional variants play a role malarial infection.
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