Asymmetric Cyanation Reactions

摘要: The asymmetric cyanation across C C, O, and N bonds ranks among the most important well-studied reactions in catalysis to achieve useful chiral building blocks for pharmaceuticals, agrochemicals, specialty materials. reaction demands careful selection of a catalyst cyanide source. A number efficient successful synthetic strategies have been developed that include cyanation-utilizing enzyme, organocatalyst, metal complexes as catalysts. As concern source cyanide, inorganic cyanides, example, NaCN KCN; organic trimethylsilyl alkyl cyanoformates, acetone cyanohydrin, acetyl cyanophosphorylates, etc. employed, depending upon targeted substrates. Since subject is vast, this chapter discusses detail chiral-metal-complex-based catalytic synthesis cyanohydrins using different sources. An attempt made discuss mechanism involved enantioselective reactions.