Imiquimod, a topical immune response modifier, induces migration of Langerhans cells.

摘要: Langerhans cells are bone marrow derived dendritic that represent the major antigen-presenting in skin. take up and process antigen within epidermis present processed to T lymphocyte regional lymph nodes thus form an integral part of cutaneous immune response. The response can be modified by a number pharmacologic agents, including corticosteroids, cyclosporine, retinoids as well physical such ultraviolet light. For most these agents act suppressing function. A topical modifier, imiquimod has been shown enhance Imiquimod anti-viral anti-tumor effects animal models approved for treatment external genital perianal warts humans. biologic activity is due its effect cytokine inducer. Preliminary data suggested could have on cells. In order clarify this cells, we examined cell morphology migration imiquimod-treated density Ia + decreased 2 d after treatment, falling approximately 43% day 10. positive remaining skin appeared larger more suggesting activated state. ATPase staining epidermal sheet confirmed To status activation B7 was examined. Activation B7-1 or B7-2 not detected. Imiquimod, however, did from draining nodes. This enhanced also associated with allergic contact hypersensitivity. These results suggest mechanism modulation