Dosing effects of an antiosteoporosis herbal formula – a preclinical investigation using a rat model
作者： Ye Sun , Simon Ming Yuen Lee , Yin Mei Wong , Ching Po Lau , Pang Chui Shaw
DOI: 10.1002/PTR.2291
关键词:
摘要: Herba Epimedii, Fructus Ligustri Lucidi and Psoraleae are three frequently used Chinese herbs traditionally for tonifying the 'kidney system'. They were selected present study to formulate an herbal preparation with a weight ratio of 5:4:1 based on their phytochemical, nature, documented treatment efficacy toxicity. The dosing effects (1 g/day, 0.5 g/day 0.175 g/day) antiosteoporosis function water extract this formula tested in ovariectomy- calcium deficiency-induced osteoporotic rats. Eleven weeks demonstrated beneficial effect preservation bone mineral density (BMD) at femur neck dose-dependent manner preference higher dosage. No significant increase uterus was observed treated In addition, microarray data kidney tissue revealed that able down-regulate expression phase II drug metabolizing enzymes, similar estrogens.
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