Mannose 6-Phosphate Receptor Dependence of Varicella Zoster Virus Infection In Vitro and in the Epidermis during Varicella and Zoster

摘要: Varicella zoster virus (VZV) is a highly infectious human pathogen; nevertheless, virions are not released in vitro where infection cell associated. Four VZV envelope glycoproteins contain mannose 6-phosphate (Man 6-P), and Man 6-P blocks of cells by cell-free VZV. Expression antisense cDNA or siRNA-like transcripts were used to generate five stable lines deficient cation-independent receptors (MPRci). All 5 MPRci-deficient resisted cell-free, but cell-associated, VZV, secreted lysosomal enzymes, when infected cell-associated Intracellular MPRci thus appear divert newly enveloped late endosomes, plasmalemmal necessary for entry Biopsies from VZV-infected skin supported the idea that because expression naturally lost maturing superficial epidermal cells, these do endosomes constitutively secrete