High CD10 expression in lymph node metastases from surgically treated prostate cancer independently predicts early death

摘要: Patients with nodal positive prostate cancers are an important cohort poorly defined risk factors. CD10 is a cell surface metallopeptidase that has been suggested to play role in cancer progression. expression was evaluated 119 patients using tissue microarrays constructed from primary tumors and lymph node metastases. All underwent radical prostatectomy standardized extended lymphadenectomy. They had no neoadjuvant therapy received deferred androgen deprivation. In the tumor, high significantly associated earlier death disease when compared low (5-year survival 73.7% vs. 91.8%; p = 0.043). metastases, larger total size of metastases (median 11.4 6.5 mm; p = 0.015), 71.5% 87.3%; p = 0.017), any cause 70.0% 87.2%; p = 0.001) expression. added independent prognostic information for overall (p = 0.029) after adjustment Gleason score tumor burden, resection margins. conclusion, predicts early death. This inherent might help personalize patient management.