CD10 protein expression in tumor and stromal cells of malignant melanoma is associated with tumor progression

摘要: CD10 antigen is a 100-kDa-cell surface zinc metalloendopeptidase expressed in variety of normal and neoplastic lymphoid nonlymphoid tissues including melanomas. It was recently shown that metastatic melanomas express more than primary tumors. We evaluated expression tumor stromal cells 70 biopsies with 28 malignant Ki-67, Bcl-2, Bax were also examined to investigate whether associated proliferation index or factors apoptosis. Formalin-fixed/paraffin-embedded studied by immunohistochemistry. More advanced tumors had higher the (r = 0.27, P 0.03 for Clark levels r 0.29, 0.02 Breslow) Ki-67 fraction 0.32, 0.007 0.001 Breslow). Similarly, intratumoral level (P 0.04, linear-by-linear association) thickness according Breslow 0.33, 0.01). The presence CD10+ peritumoral cell cuffs positively 0.05). Also, significantly 0.01 respectively), but Bcl-2 0.02). conclude melanoma progression.