Inhibition of SIRT2 limits tumour angiogenesis via inactivation of the STAT3/VEGFA signalling pathway.

摘要: Mounting evidence has demonstrated that angiogenesis plays an important role in tumour progression. However, the key regulators remain unclear. Recently, emerging reports have indicated SIRT2 critical roles proliferation, metastasis and tumourigenesis diverse tumours. function of mechanism underlying regulation by are still unknown. Here, we found was upregulated colorectal cancer tissues compared to normal samples elevated associated with poor prognosis patients cancer. In addition, a series vitro vivo experiments were performed demonstrate angiogenesis. We showed silencing significantly suppressed Mechanistically, knockdown inhibited STAT3 phosphorylation, causing decreased secretion VEGFA. Notably, directly interacted affected phosphorylation translocation phosphorylated nucleus. Importantly, rescue suggested depends on STAT3/VEGFA signalling pathway. Our findings provide insight into colon suggest SIRT2/STAT3/VEGFA might be novel prognostic biomarker potential therapeutic target for