Polarimetric imaging of amyloid

作者: Werner Kaminksy , Lee-Way Jin , Steven Powell , Izumi Maezawa , Kacey Claborn

DOI: 10.1016/J.MICRON.2005.10.014

关键词:

摘要: New developments in optical microscopy are discussed with relevance to the imaging of amyloid plaques that pathognomonic a variety degenerative disorders. We present results linear birefringence, dichroism, and circular dichroism Congo red stained ex vivo vitro. A new technique for measuring rapid changes anisotropies is introduced. The application polarimetric as demonstrated here can be extended broader pathological practice since measurements sensitive transformations tissues specific disease signatures.

参考文章(106)
R N Miranda, L J Medeiros, R N Nayak, P J Kragel, C D Wu, Amyloid in adrenal gland pheochromocytomas. Archives of Pathology & Laboratory Medicine. ,vol. 119, pp. 827- 830 ,(1995)
Piekarska B, Roterman I, No Kt, Pawlicki R, Rybarska J, Konieczny L, Kaszuba J, Bis azo dyes--studies on the mechanism of complex formation with IgG modulated by heating or antigen binding. Journal of Physiology and Pharmacology. ,vol. 44, pp. 213- ,(1993)
Nobuyuki Harada, Kōji Nakanishi, Circular dichroic spectroscopy : exciton coupling in organic stereochemistry University Science Books. ,(1983)
Nina Berova, Robert W. Woody, 香爾 中西, Circular Dichroism: Principles and Applications ,(1994)
Colin J. Barrow, Akikazu Yasuda, Peter T.M. Kenny, Michael G. Zagorski, Solution conformations and aggregational properties of synthetic amyloid beta-peptides of Alzheimer's disease. Analysis of circular dichroism spectra. Journal of Molecular Biology. ,vol. 225, pp. 1075- 1093 ,(1992) , 10.1016/0022-2836(92)90106-T
Westermark P, The pathogenesis of amyloidosis: understanding general principles. American Journal of Pathology. ,vol. 152, pp. 1125- 1127 ,(1998)
R. Clark Jones, A New Calculus for the Treatment of Optical SystemsI Description and Discussion of the Calculus Journal of the Optical Society of America. ,vol. 31, pp. 488- 493 ,(1941) , 10.1364/JOSA.31.000488