Pulsed radiation studies of photodynamic sensitisers: the nature of DHE.

摘要: Laser flash photolysis has previously been used to study the nature of DHE via measurements photophysical parameters which are dependent on molecular weight system being studied. These results date allow only a lower limit be established for imply that in some environments such as detergents more than two porphyrin units linked. We have now determined triplet extinction coefficient by pulse radiolysis technique an energy transfer method allows estimated independent weight. The combined techniques actual at about 4200. also determine, number potential photodynamic sensitisers, quantum yield state formation (θT) and, using direct luminescence singlet oxygen 1270 nm, (θδ). For many porphyrins studied θδ is less θT. itself there substantial increase detergent compared buffer. yields related systems including 'simple’systems haematoporphyrin, linked porphyrin-chlorin systems, (including end reduced chlorin–DHEC), and phthalocyanines compared. DHEC close may chlorins could use therapy (PDT).