Involvement of the early growth response protein 1 in vascular pathophysiology: an overview.

作者： Viktoria Youreva , Estelle R Simo Cheyou , Ashok K Srivastava

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摘要: Hyperactivation of proliferative and growth promoting pathways underlies the progression vessel remodeling, leading to vascular dysfunction. An upregulation early response protein 1 (Egr-1), a zinc finger transcription factor has been observed in several models diseases. In vasculature, Egr-1 expression can be induced by multiple hormonal, metabolic external stimuli, such as factors, cytokines, reactive oxygen species, hyperglycaemia stretch-induced stress. The structure promoter allows both its auto-regulation binding with regulatory cofactors like serum cAMP element protein. Pharmacological genetic studies have revealed involvement signaling that contribute Egr-1. Among them, mitogen-activated kinase pathway emerged predominant cascade regulates various stimuli. Moreover, targeted deletion DNAzymes, antisense oligonucleotides or RNA interference also helped defining importance pathophysiology Neointimal formation genes directly linked proinflammatory processes demonstrated enhanced activity. This review provides an overview on components implicated discusses potential pathophysiology.

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Involvement of the early growth response protein 1 in vascular pathophysiology: an overview.

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Involvement of the early growth response protein 1 in vascular pathophysiology: an overview.

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