A novel approach based on capillary electrophoresis coupled to augmented multivariate curve resolution-alternating least-squares modeling for the determination of pKa of 2-hydroxy-4,6-dimethylpyrimidine in nicarbazin
作者： Carla M. Teglia , Romina Brasca , Luciana Vera-Candioti , Héctor C. Goicoechea
DOI: 10.1016/J.CHEMOLAB.2015.11.001
关键词:
摘要: Abstract The determination of the dissociation constant 2-hydroxy-4,6-dimethylpyrimidine in nicarbazin was carried out by means capillary electrophoresis using a dynamic coating fused-silica with high-molecular-mass poly(diallyldimethylammonium chloride) (PDDA) implementing two methods: (a) fitting effective mobility determined from different electrophoretic runs at single wavelength as function pH and (b) novel modeling strategy spectrophotometric second-order data generated diode array detector several wavelengths pH. accuracy proposed methodologies verified robenidine model compound known value pKa.
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