Specific Adoptive Therapy of Disseminated Tumors

摘要: There is little difficulty demonstrating under experimental conditions that T cells can specifically recognize and kill autochthonous or MHC-compatible tumor cells. However, the all too common observation neoplastic develop grow progressively in apparently immunocompetent hosts suggests cellular immune response an inadequate defense mechanism for protection from fatal tumors. are many reasons why host system may be ineffective controlling growth. The most obvious, problematic with regard to immunologic intervention, not express any determinants immunogenic host. Although some tumors lack such determinants, a substantial amount of evidence accumulating suggest do potentially surface antigens. presence these antigens on implies during progressive growth have elicited quantitatively response, induced suppressor which down-regulated response. Recent technologic biologic advances made it possible purify potential effector identify weak antigen-specific T-cell responses by expanding number reactive vitro culture. Application techniques analysis has permitted detection apparent tumor-specific immunity cancer patients variety solid hematologic malignancies.(1–6) Thus, methods augment being explored as therapies.