Long-term Clinical Significance of Thyroid Autoimmunity in Children with Celiac Disease

摘要: Objective To evaluate the long-term outcome of thyroid function and autoimmunity in a large series children with celiac disease. Study design This longitudinal, retrospective study (duration follow-up, 8.9 ± 4.0 years) was conducted at Pediatric Department, University Bologna, Italy. One hundred thirty-five consecutive patients diagnosed between June 1990 December 2004 followed on gluten-free diet were examined. Inclusion criteria good dietary compliance duration follow-up for least 3 years. Results Of 101 who never showed positive antithyroid titers during 86 remained euthyroid; 15 high thyroid-stimulating hormone values diagnosis that normalized 11 cases after 12 to 18 months gluten withdrawal. 31 persistently antibody titers, 23 (74%) consistently euthyroid 8 (26%) had subclinical hypothyroidism. The prevalence antibodies similar growth retardation or gastroenterological symptoms different durations exposure. Conclusions presence disease has low predictive value for the development hypofunction indicated surveillance period. Longer is needed.