Homogeneously Cross-Linked Scaffolds Based on Clinical-Grade Alginate for Transplantation and Tissue Engineering

摘要: Transplantation of therapeutic allogenic tissues or genetically manipulated cells without immunosuppression is a promising strategy for the long-term treatment various hormone deficiencies and neuro-degenerative diseases in human [9, 8, 18]. To achieve this promise, host reactions against transplants must be prevented by encapsulation microcapsule. A major problem precise adjustment numerous matrix- host-related parameters to need immunoisolation, while not impeding simultaneously inward transport nutrients oxygen release generated factors from microcapsule core. Numerous animal studies recent pilot clinical trials have shown feasibility alginate-based microcapsules immunoisolated transplantation [5, Alginate also has many potential advantages as tissue engineering matrix [2,14]. The primary challenge field regenerative medicine promote formation missing non-functioning specialized autologous cells. Repair articular cartilage lesions mesenchymal stem chrondrocytes one key applications. In case, alginate serves three-dimensional scaffold promotion re-differentiation hyaline vitro expanded de-differentiated