Decreased Bacterial Diversity Characterizes the Altered Gut Microbiota in Patients With Psoriatic Arthritis, Resembling Dysbiosis in Inflammatory Bowel Disease

摘要: Objective To characterize the diversity and taxonomic relative abundance of gut microbiota in patients with never-treated, recent-onset psoriatic arthritis (PsA). Methods High-throughput 16S ribosomal RNA pyrosequencing was utilized to compare community composition PsA (n = 16), psoriasis skin 15), healthy, matched control subjects 17). Samples were further assessed for presence levels fecal serum secretory IgA (sIgA), proinflammatory proteins, fatty acids. Results The observed less diverse when compared that healthy controls. This could be attributed reduced several taxa. from both patient groups showed a decrease Coprococcus species, while samples also characterized by significant reduction Akkermansia, Ruminococcus, Pseudobutyrivibrio. Supernatants revealed an increase sIgA RANKL levels. Analysis acids low quantities hexanoate heptanoate psoriasis. Conclusion Patients had lower multiple intestinal bacteria. Although some genera concomitantly decreased conditions, reportedly beneficial profile similar previously described inflammatory bowel disease associated changes specific proteins unique this group, distinct Thus, role microbiome continuum psoriasis–PsA pathogenesis immune response merits study.