Chapter 14 Cerebral vascular dysregulation in the ischemic brain

摘要: Publisher Summary This chapter describes the cerebral vascular dysregulation in ischemic brain. Cerebral ischemia produces profound alterations of major control mechanisms governing circulation. results a disruption cerebrovascular regulatory that assure brain is adequately perfused. impairs autoregulation, attenuates functional hyperemia, and alters hypercapnic vasodilation, critical by which active cells maintain homeostasis their microenvironment through delivery nutrients removal waste. These are large part mediated surge free radicals, leads to neurovascular oxidative stress function neurons, glia, cells. regulation render more vulnerable changes perfusion pressure metabolic dysfunction induced ischemia, thereby increasing susceptibility tissue injury. The introduction techniques for measuring regional blood flow (CBF) provides new insights into CBF distribution following focal or global ischemia. Therapeutic strategies targeting offer opportunity preserve postischemic improve outcome Such vaso-protective approach, combination with cytoprotective therapies, may open avenues treatment stroke.