Lentivirus: A Vector for Nervous System Applications

摘要: Vectors based on lentiviruses are opening up new approaches for the treatment of neurological disease and damage. They efficiently deliver genes into many different types primary neurons from a broad range species including human, resulting gene expression is longterm non-toxic. Numerous animal studies have now been undertaken with these vectors, correction models has obtained. These vectors refined to very high level, they ready clinical evaluation (reviewed in Martin-Rendon et al. 2001; Deglon Aebischer 2002). This review will describe general features lentiviral particular emphasis derived non-primate lentivirus, equine infectious anaemia virus (EIAV), then give some key examples transfer genetic diseases. The prospects human be outlined.