Aldosterone-Producing Adrenocortical Carcinoma

摘要: In 1955 Conn described the syndrome of primary hyperaldosteronism (PHA) [1], which has come to be known as “Conn’s Syndrome” [2]. PHA is a group disorders in aldosterone production inappropriately high, relatively autonomous from renin-angiotensin system, and nonsuppressible by sodium loading. Such inappropriate causes cardiovascular damage, suppression plasma renin, hypertension, retention, potassium excretion that if prolonged severe may lead hypokalemia. commonly caused adenoma (35%), bilateral adrenal hyperplasia (60%), or (rarely) producing adrenocortical carcinoma (APAC) (<1%) (Table 27.1) [3]. The first APAC was reported Foye Feichtmeir [4] shortly after Conn’s original report. Aldosterone hypersecretion (ACC) rare with only 58 patients being recent review [5]. numbers amongst ACCs vary significantly. one large series ACCs, 2.5% had developed [6]. single center analysis on were subjected operative management at Mayo Clnic, portion APACs 11%. Conversely, it been estimated due 1% [7].