Optimization Approaches for the Design of Additively Manufactured Scaffolds

摘要: Scaffolds play a pivotal role in tissue engineering, promoting the synthesis of neo extra-cellular matrix (ECM), and providing temporary mechanical support for cells during regeneration. Advances introduced by additive manufacturing techniques have significantly improved ability to regulate scaffold architecture, enhancing control over shape porosity. Thus, considerable research efforts been devoted fabrication 3D porous scaffolds with optimized micro-architectural features. This chapter gives an overview methods design additively manufactured their applicability engineering (TE). Along survey state art, Authors will also present recently developed method, called Load-Adaptive Scaffold Architecturing (LASA), which returns architectures given applied loads systems, once specific stress distribution is evaluated through Finite Element Analysis (FEA).