Combined treatment with cyclophosphamide and prednisolone is effective for secondary amyloidosis with SAA1γ/γ genotype in a patient with rheumatoid arthritis.
作者： T. Nakamura , S. Baba , Y. Yamamura , T. Tsuruta , S. Matsubara
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摘要: A 41-year-old woman, who had been diagnosed with rheumatoid arthritis (RA), was admitted because of proteinuria, and gastrointestinal symptoms just 1 year after onset. Renal biopsy revealed marked amyloid deposits AA (amyloid A)-type. Genotyping serum (SAA) showed that she homozygous for SAA1γ. Combined treatment cyclophosphamide prednisolone led to remission both RA disease activity proteinuria. Since the renal dysfunction arose from amyloidosis, arrested deterioration a proteinuria would result reduction deposits. Therefore, early usage immunosuppresive therapy such as combined these two medicines be useful against systemic amyloidosis secondary RA, even if patient has risky SAA1γ/γ genotype.
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