Tissue-specific alterations of PRL-1 and PRL-2 expression in cancer

摘要: The PRL-1 and PRL-2 phosphatases have been implicated as oncogenic, however the involvement of these molecules in human neoplasms is not well understood. To increase understanding role play neoplastic process, situ hybridization was used to examine mRNA expression 285 normal, benign, malignant tissues diverse origin. Immunohistochemical analysis performed on a subset these. also assessed small set samples from variety diseases other than cancer. Where possible, associations with clinicopathological characteristics were evaluated. Alterations or -2 frequent event, but nature those alterations highly tumor type specific. significantly overexpressed 100% hepatocellular gastric carcinomas, under-expressed ovarian, 80% breast, 75% lung tumors. increased yet downregulated 54% kidney carcinomas. correlated patient gender bladder age brain skeletal muscle. associated grade prostate, ovary, uterus. These results suggest pleiotropic for process. may associate progression serve clinical markers aggressiveness some tissues, be involved inhibition formation growth others.